In the present atmosphere, numerous macro and micro-branches and faculties of education have emerged. Several minute branches have come out of a particular subject. So it has become difficult for the astrologers to find out astrologically the subject, a native will choose. Biotechnology is one such subject which has become popular in recent times. Let us try to find out the planetary significations and combinations for the study of Biotechnology in the present research article. Biotechnology consists of two terms Biology and technology. It is the use of living systems and organisms to develop or manufacture useful products. Biotechnology encompasses a wide range of procedures for modifying living organisms according to human purposes. Biotechnology has applications in four major varied industrial areas including healthcare, agriculture, industries, and foodstuffs. Thus Biotechnology is the application of science and technology to living organisms. Therefore, the role of many important planets signifying the particular area come into play. Jupiter is the planet of living organisms (the Jeeva). Saturn and Mars are considered to be the technical planets, so their role is also prominent. In Biotechnology chemical processing also takes place, so the Rashis and the Planets representing water element also come to the forefront. Moon is considered to be the planet representing water elements. So, it is essential to take into accounts the combination of all above-mentioned factors while deciding the study of Biotechnology by a particular native. For the knowledge and convenience of the readers, it has been illustrated by the following two examples where the natives got the education of Biotechnology due to the combined effects of various astrological factors viz. the concerned planets, rashis and the favorable dashes for the study of Biotechnology.